Bisous  For Léo
Bisous For Léo's Fundraiser

HELP LÉO KISS INAD GOODBYE

Share your bisous to help us find a cure

$298,489 towards $558,625

Bisous For Léo

When a child gets hurt, a typical response might be "kiss it to make it feel better."
This method works in most cases; however, for Léo Vauclare it's not so simple.

Born in France to a Parisian father and an American mother, the energetic two-year-old was recently diagnosed with a rare, genetic, neurodegenerative disease called INAD (Infantile Neuroaxonal Dystrophy), or in simpler terms, "Parkinson's mixed with Alzheimer's, affecting kids."

Léo developed like a typical child well into his first year, but soon after, his parents, Deborah and Antoine, noticed a developmental regression. After much testing, the diagnosis was rendered. Eventually, he will lose all acquired skills including mental and cognitive abilities, as seen in Alzheimer's, and physical abilities, as seen in Parkinson's, resulting in his death likely before he's ten years old. While there are currently no known treatments or cures, we would like to change that, not only for Léo but for other children diagnosed with this devastating disease.

One of the most common questions we get asked is why it is important to fund such a rare disease and we are ready with a resounding “wow-inducing” answer to this question – further understanding of INAD could in turn help to develop new treatments and ultimately a cure for some forms of Parkinson’s Disease, Alzheimer’s, and Lewy Body Dementia. There have been numerous studies that address the link between INAD (PLA2G6 mutation) and these other neurodegenerative diseases. And these neurodegenerative diseases impact 50 plus million people around the world!

Dr. Paul T. Kotzbauer, MD, Ph.D., and professor in the department of neurology at Washington University School of Medicine is one of the lead doctors helping us fight the good fight. His current research is focused on understanding disease mechanisms and developing improved diagnostic and therapeutic approaches in Parkinson's disease and in the hereditary neurological disorder NBIA - Neurodegeneration with Brain Iron Accumulation, under which INAD falls.

As explained by Dr. Kotzbauer, "I have been able to identify a definitive link between Parkinson's disease and INAD. Accumulation of the alpha-synuclein protein, a defining feature of Parkinson's disease, also occurs in INAD, affecting the same regions of the central nervous system. Thus, further understanding of these two neurodegenerative disorders will help to develop new treatments and ultimately a cure.” To learn more click here!

As affirmed by J. Paul Taylor, M.D., Ph.D., Faculty Member, Chair of Cell and Molecular Biology Department at St. Jude Children’s Research Hospital and Howard Hughes Medical Institute Investigator, “Mutations in PLA2G6 have been associated with other brain disorders, such as Parkinson’s and Alzheimer’s diseases. Research shows that some INAD patients present Lewy bodies and neurofibrillary tangles in the brain, which suggests shared pathogenesis. Supporting science aimed towards a better understanding of INAD and PLA2G6 gene mutations could also benefit the other brain diseases in which PLA2G6 has been implicated.”

Bisous For Léo raises funds to benefit the INADcure Foundation. The INADcure Foundation is the only U.S.-based nonprofit dedicated to the INAD community. It was formed to fund scientific research for treatments and a cure for INAD and other forms of PLA2G6-related neurodegeneration (PLAN).

The INADcure Foundation is committed to bringing breakthrough treatments, and one day a cure, to all children living with INAD. Current research initiatives include:

  1. Gene Therapy Research in partnership with Washington University in St. Louis
  2. Compound Screening in partnership with Baylor College of Medicine
  3. INAD BioBank in partnership with the New York Stem Cell Foundation
  4. Gene Editing/Cell Therapy Initiative in partnership with the New York Stem Cell Foundation
  5. PLANready Natural History Study in partnership with Oregon Health and Science University

With the money raised, our kisses, or bisous as they say in French,
will help us kiss INAD goodbye 💋


FOLLOW US ON SOCIAL MEDIA:

Help us kiss INAD goodbye, not just for Leo but for all children affected by the disease.
People from all around the world have been posting their kisses (or Bisous as they say in French)
and tagging Bisous for Léo to help raise awareness.

Gal Gadot Bisous Laura Dern Bisous Andy Cohen Bisous Priyanka Chopra Bisous

BisousforLeo @BisousforLeo ......... Bisous for Leo Bisous for Léo


RECENT PRESS:


SHOP FOR OUR CAUSE:

BISOUS FOR LEO BOOK:
💋 100% of the proceeds from this book benefit the cause 💋
Please click here: to purchase the Bisous For Léo book.

Bisous for Leo Book


Our Bookstore: our carefully curated collection of great books for children and adults!

Bisoue for Leo Bookshop


Stay safe, but make it fashion for a cause!
100% of proceeds from the sale of these masks will benefit Bisous For Léo 💋
Lips Only Mask.. ..................................................... Logo Mask
.........


Below are our Affiliate links, any purchases made using these links will benefit Bisous For Léo

Etsy - shop for handmade, vintage, custom, & unique gifts . Meri Meri - shop for whimsical, modern, high-quality party supplies

foodstirs - shop junk-free baking mixes & pre-packaged mini donuts, mini muffins & brownie bites . Rockets of Awesome - Stylish, comfortable children's clothing subscription boxes


Shop our Bisous Gift Guide here!
(After opening the link, click directly on the red boxes to shop for the cause)

Bisous for Leo Gift Guide

INFOGRAPHIC:

Click the image below to see a full-sized Infographic about INAD:

Bisous for Leo: Infantile Neuroaxonal Dystrophy Infographic